Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction

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Abueid L., USLU Ü., Cumbul A., Ogunc A. V., ERCAN F., Alican I.

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.17, no.4, pp.269-275, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.14744/anatoljcardiol.2016.7248
  • Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.269-275
  • Keywords: cyclooxygenase, ischemia/reperfusion, myocardial infarction, rat, zileuton, 5-lypoxygenase, ISCHEMIA-REPERFUSION INJURY, CEREBRAL-ISCHEMIA, KNOCKOUT MICE, KAPPA-B, PROSTAGLANDIN, ACTIVATION, APOPTOSIS, CYCLOOXYGENASE-2, BIOSYNTHESIS, INFLAMMATION
  • Akdeniz University Affiliated: No

Abstract

Objective: The goal of the present study was to investigate the effects of 5-lipoxygenase (5-LOX) inhibition, alone and with cyclooxygenase (COX) inhibitors, on inflammatory parameters and apoptosis in ischemia/reperfusion (I/R)-induced myocardial damage in rats. For this purpose, zileuton, a selective and potent inhibitor of 5-LOX, resulting in suppression leukotriene production, was used.