Potential utility of p63 expression in differential diagnosis of non-small-cell lung carcinoma and its effect on prognosis of the disease

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Bir F., AKSOY ALTINBOĞA A., Satiroglu-Tufan N. L., Kaya S., BAŞER S., YAREN A.

MEDICAL SCIENCE MONITOR, vol.20, pp.219-226, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2014
  • Doi Number: 10.12659/msm.890394
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.219-226
  • Keywords: Carcinoma, Non-Small-Cell Lung - pathology, Diagnosis, Differential, Reverse Transcriptase Polymerase Chain Reaction - methods, IMMUNOHISTOCHEMICAL MARKERS, P53 HOMOLOG, CANCER, CLASSIFICATION, ADENOCARCINOMA, EPITHELIUM, SURVIVAL, P73
  • Akdeniz University Affiliated: Yes

Abstract

Background: P63 is a gene located in chromosome 3q27-29, which has been implicated in regulation of stem cell commitment and promotion of squamous differentiation in various tissues. The aim of this study was to investigate whether there was a correlation between p63 expression, differential diagnosis of lung carcinoma, and prognosis.