The role of cytochrome P450 pharmacogenomics in chronic non-cancer pain patients

Tverdohleb T., Dinc B., Knezevic I., Candido K. D., Knezevic N. N.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, vol.12, no.11, pp.1303-1311, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 12 Issue: 11
  • Publication Date: 2016
  • Doi Number: 10.1080/17425255.2016.1209482
  • Journal Name: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1303-1311
  • Keywords: Chronic pain, cytochrome P450, CYP2D6, opioids, pharmacogenomics, CYP2D6 GENE DUPLICATION, BREAST-FED NEONATE, HUMAN LIVER, ULTRARAPID-METABOLISM, ALLELE FREQUENCY, ACTIVITY SCORE, GUINEA-PIG, CODEINE, HYDROCODONE, OXYCODONE
  • Akdeniz University Affiliated: Yes

Abstract

Introduction: Pharmacogenomics is the field that studies an individualized treatment approach for patients' medication regimen that can impact drug safety, productivity, and personalized health care. Pharmacogenomics characterizes the genetic differences in metabolic pathways which can affect a patient's individual responses to drug treatments.