Hybrid Tomo-Helical and Tomo-Direct radiotherapy for localized prostate cancer


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Karaca S., Koca T., Sarpün İ. H., Tunçel N., Korcum Şahin A. F.

JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, cilt.22, sa.10, ss.136-143, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/acm2.13406
  • Dergi Adı: JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Applied Science & Technology Source, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.136-143
  • Anahtar Kelimeler: hybrid radiotherapy, localized prostate cancer, Tomo-Direct, Tomo-Helical, MODULATED ARC THERAPY, RADIATION-THERAPY, CONVENTIONAL RADIOTHERAPY, CONFORMAL RADIOTHERAPY, 70 GY, DOSIMETRY, TOXICITY, IMRT
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose The aim of the study is to present a new planning approach to provide better planning target volume (PTV) coverage and reduce bladder and rectum dose with hybrid Tomo-Helical (TH)/Tomo-Direct (TD) radiotherapy (RT) for localized prostate cancer (LPC). Methods Twenty-five LPC patients were included in this retrospective study. TH plans, TD plans, and hybrid TH/TD plans were created. Lateral beams were used for the hybrid TD plan and the prescribed dose was 70 Gy in 28 fractions (hybrid plans were combined 45 Gy/ 18 fxs for TH and 25 Gy/10 fxs for TD). Doses of PTV (D2%, D98%, D50%, homogeneity index (HI), conformity index (CI), coverage) and organs at risk (OARs) (V50%, V35%, V25%, V5%, and V95%) were analyzed. The Wilcoxon signed-rank test was used to analyze the difference in dosimetric parameters. p-Value TH plans showed better CI, and target coverage (p < 0.01) than TD and hybrid plans in all patient plan evaluations. However, TD plans D2%, D98%, and D50% doses were better than TH and hybrid plans. The HI values were similar between the three plans. Significant reductions in bladder and rectum V50%, V35%, and V25% doses (p < 0.001) were observed with hybrid plans compared to TH and TD. Penile bulb V95% and bowel V5% doses were better in the hybrid plans. Left and right femoral head V5% doses were higher in the hybrid plan compared to others (p < 0.001). Conclusion Concurrently hybrid TH/TD RT plan can be a good option to reduce the doses of the rectum and bladder in the RT of LPC.