Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31

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OZTURK A., NAHED B., BYDON M., BILGUVAR K., Goksu E. T., BADEMCI G., ...More

STROKE, vol.37, no.4, pp.1021-1027, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2006
  • Doi Number: 10.1161/01.str.0000206153.92675.b9
  • Journal Name: STROKE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1021-1027
  • Keywords: aneurysm, genetics, ABDOMINAL AORTIC-ANEURYSMS, GENOME-WIDE LINKAGE, SUBARACHNOID HEMORRHAGE, CEREBRAL ANEURYSMS, CHROMOSOME 19Q13.3, CANDIDATE GENES, FAMILIES, LOCUS, CONFIRMATION, HYPERTENSION
  • Akdeniz University Affiliated: Yes

Abstract

Background and Purpose - Both environmental and genetic factors contribute to the formation, growth, and rupture of intracranial aneurysms (IAs). To search for IA susceptibility genes, we took an outlier approach, using parametric genome-wide linkage analysis in extended IA kindreds in which IA is inherited as a simple Mendelian trait. We hereby present the molecular genetic analysis of 2 such families.