High TRAIL Death Receptor 4 and Decoy Receptor 2 Expression Correlates With Significant Cell Death in Pancreatic Ductal Adenocarcinoma Patients

ŞANLIOĞLU A. D., Dirice E., Elpek O., Korcum A. F., OZDOGAN M., SÜLEYMANLAR İ., ...Daha Fazla

PANCREAS, cilt.38, sa.2, ss.154-160, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1097/mpa.0b013e31818db9e3
  • Dergi Adı: PANCREAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.154-160
  • Anahtar Kelimeler: TRAIL, pancreas, ductal adenocarcinoma, cell death, APOPTOSIS-INDUCING LIGAND, GENE-THERAPY, DIFFERENTIAL EXPRESSION, DECREASED SURVIVAL, CANCER CELLS, RESISTANCE, CARCINOMA, PATHWAY, MECHANISMS, PROTEIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives: The importance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptor expression in pancreatic carcinoma development is not known. To reveal the putative connection of TRAIL and TRAIL receptor expression profile to this process, we analyzed and compared the expression profile of TRAIL and its receptors in pancreatic tissues of both noncancer patients and patients with pancreatic ductal adenocarcinoma (PDAC).