High TRAIL Death Receptor 4 and Decoy Receptor 2 Expression Correlates With Significant Cell Death in Pancreatic Ductal Adenocarcinoma Patients

ŞANLIOĞLU A. D., Dirice E., Elpek O., Korcum A. F., OZDOGAN M., SÜLEYMANLAR İ., ...More

PANCREAS, vol.38, no.2, pp.154-160, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1097/mpa.0b013e31818db9e3
  • Journal Name: PANCREAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.154-160
  • Keywords: TRAIL, pancreas, ductal adenocarcinoma, cell death, APOPTOSIS-INDUCING LIGAND, GENE-THERAPY, DIFFERENTIAL EXPRESSION, DECREASED SURVIVAL, CANCER CELLS, RESISTANCE, CARCINOMA, PATHWAY, MECHANISMS, PROTEIN
  • Akdeniz University Affiliated: Yes

Abstract

Objectives: The importance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptor expression in pancreatic carcinoma development is not known. To reveal the putative connection of TRAIL and TRAIL receptor expression profile to this process, we analyzed and compared the expression profile of TRAIL and its receptors in pancreatic tissues of both noncancer patients and patients with pancreatic ductal adenocarcinoma (PDAC).