Recurrent bullous lesions associated with familial Mediterranean fever: a case report

AKMAN A., Cakcak D. S., Coban E., Ozbudak H. I., Ciftcioglu M. A., ALPSOY E., ...Daha Fazla

CLINICAL AND EXPERIMENTAL DERMATOLOGY, cilt.34, sa.2, ss.216-218, 2009 (SCI-Expanded, Scopus)

Özet

Familial Mediterranean fever (FMF) is an inherited, recurrent, inflammatory disease. Of its various cutaneous features, erysipelas-like erythema is the best known and most common skin lesion. We present a new case of FMF with recurrent bullous lesions. A 41-year-old woman was admitted to our clinic with tense bullae, 20 x 20 mm in diameter on the left shin. The patient had a history of fever, abdominal pain, peritonitis attacks and infertility. A lesional skin biopsy revealed subepidermal bullae and neutrophilic infiltration around dermal vessels. Direct immunofluorescence analysis was negative. Over the period of investigation, the lesion regressed spontaneously; 1 month later, a similar lesion appeared on the right wrist. Diagnosis of FMF was made according to the Tel-Hashomer criteria. Recognition of this peculiar skin lesion may lead to an earlier diagnosis of the disease.