Hemodialysis is the most common renal replacement therapy in the treatment of chronic kidney disease. Adherence to treatment is important in hemodialysis which is a complex treatment process. Adherence to treatment includes fluid intake, diet, drug management and participation in dialysis sessions. In hemodialysis patients, many problems may arise due to nonadherence to treatment. Watson's Theory of Human Caring (THC) is the one of the important theories used to understand these problems and adaptation difficulties and to develop appropriate coping methods. Watson's THC enables individuals to be evaluated in a holistic manner, adapt to the disease and treatment process, and recover. This review, which was prepared as a result of the literature review, was prepared to raise awareness about nursing care based on Watson's THC in ensuring compliance with treatment in individuals undergoing hemodialysis therapy.