Serological Diagnosis of Autoimmune Blistering Diseases

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Ozkesici B., AKMAN KARAKAŞ A.

TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY, cilt.10, sa.1, ss.1-8, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4274/tdd.2016.10.01.01
  • Dergi Adı: TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Autoimmune blistering diseases, diagnosis, immunofluorescence findings, biochip, Enzyme Linked Immunosorbent Assay, LINKED-IMMUNOSORBENT-ASSAY, EPIDERMOLYSIS-BULLOSA ACQUISITA, INDIRECT IMMUNOFLUORESCENCE, PARANEOPLASTIC PEMPHIGUS, SKIN DISEASES, DESMOGLEIN 1, RECOMBINANT DESMOGLEINS, SUBSTRATE-SPECIFICITY, AUTOANTIBODY LEVELS, VII COLLAGEN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Autoimmune blistering diseases are a rare diseases, characterized by development of autoantibodies against the structural proteins of the epidermis or dermoepidermal junction, and blisters and erosions on skin and/or mucous membranes clinically. Clinical features are important guiding findings for suspicious of this group of diseases. The diagnosis is achieved by the evaluation together of clinical features, histological and immunological findings. The gold standard in the diagnosis of this group diseases are demonstration of tissue bound and/or circulating autoantibodies. Methods for this purpose are; direct and indirect immunofluorescence, Enzyme Linked Immunosorbent Assay (ELISA), immunoprecipitation and immunoblotting. The aim of this paper is to review serological diagnostic methods in the diagnosis of autoimmune bullous diseases and to present developments in recent years.