The effect of cetirizine on IFN-gamma and IL-10 production in children with allergic rhinitis

UGUZ A., Sanlioglu S., YUZBEY S., COSKUN M., Yegin O.

TURKISH JOURNAL OF PEDIATRICS, vol.47, no.2, pp.111-115, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2005
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.111-115
  • Keywords: allergic rhinitis, cetirizine, IFN-gamma, IL-10, IL-4, CELLS, INTERLEUKIN-5, THERAPY, SAFETY, DRUG
  • Akdeniz University Affiliated: Yes

Abstract

Cetirizine, one of the most commonly used antihistamines for the treatment of allergic diseases, possesses some anti-inflammatory properties. Despite its common use, the effect of cetirizine on the production of cytokines from peripheral blood mononuclear cells (PBMCs) needs further clarification. The aim of this study was to investigate whether cetirizine changes interleukin (IL)-10, (IF)-gamma and IL-4 production from PBMCs in children with allergic rhinitis.