Comparison of three different doses of intrathecal levobupivacaine in urological surgery

ŞEN H., Akbaş M., SIZLAN A., ATEŞ F., DERE K., GÜNDÜ I., ...More

Trakya Universitesi Tip Fakultesi Dergisi, vol.26, no.3, pp.214-219, 2009 (SCI-Expanded, Scopus, TRDizin)

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2009
  • Journal Name: Trakya Universitesi Tip Fakultesi Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.214-219
  • Keywords: Intrathecal, levobupivacaine, analgesia, anesthesia, SPINAL-ANESTHESIA, RACEMIC BUPIVACAINE, S(-)-BUPIVACAINE, VOLUNTEERS
  • Akdeniz University Affiliated: Yes

Abstract

Objectives: The aim of our study was to compare the efficacy of hyperbaric and isobaric solutions of intrathecal levobupivacaine for transurethral endoscopic surgery. Patients and Methods: The study included urological patients who were scheduled for elective surgery under spinal anesthesia. The cases were randomly divided into three groups of 20 patients each. Group 1 received 13.5 mg hyperbaric levobupivacaine, group 2 received 12.5 mg isobaric levobupivacaine and group 3 received 15 mg isobaric levobupivacaine in a total volume of 3 ml intrathecally. Sensory and motor block, hemodynamic parameters, pain scores, adverse effects and analgesic requirements of the patients were recorded. Results: The time to reach T10 sensory block and the onset time to Bromage 0 were statistically different among the three groups (p<0.05). The mean time to reach T10 was significantly lower in group 1 when compared with group 2 (p<0.001). Regarding the mean onset time to Bromage 0, group 1 had a lower mean value than that of group 3 (p<0.001). The mean duration for analgesic requirement was longer in group 1 than in groups 2 and 3 (p<0.001 and p<0.05, respectively). Conclusion: We concluded that the clinical efficacy of hyperbaric levobupivacaine was superior to the isobaric forms in spinal anesthesia for transurethral endoscopic surgery. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.