The shaping and functional consequences of the dosage effect landscape in multiple myeloma

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Samur M. K., Shah P. K., Wang X., Minvielle S., Magrangeas F., Avet-Loiseau H., ...More

BMC GENOMICS, vol.14, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2013
  • Doi Number: 10.1186/1471-2164-14-672
  • Journal Name: BMC GENOMICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Copy number alteration, Dosage effect, Multiple myeloma, Hyperdiploid, Integrative genomics, GENE-EXPRESSION, COPY-NUMBER, INTEGRATIVE ANALYSIS, ANEUPLOIDY, IDENTIFICATION, PATHOGENESIS, IMBALANCES, INHIBITOR, APOPTOSIS, GENOMICS
  • Akdeniz University Affiliated: No

Abstract

Background: Multiple myeloma (MM) is a malignant proliferation of plasma B cells. Based on recurrent aneuploidy such as copy number alterations (CNAs), myeloma is divided into two subtypes with different CNA patterns and patient survival outcomes. How aneuploidy events arise, and whether they contribute to cancer cell evolution are actively studied. The large amount of transcriptomic changes resultant of CNAs (dosage effect) pose big challenges for identifying functional consequences of CNAs in myeloma in terms of specific driver genes and pathways. In this study, we hypothesize that gene-wise dosage effect varies as a result from complex regulatory networks that translate the impact of CNAs to gene expression, and studying this variation can provide insights into functional effects of CNAs.