Are uremia, diabetes, and atherosclerosis linked with impaired antioxidant mechanisms?

Dursun B., Dursun E., Çapraz I., Ozben T., Apaydın A., SÜLEYMANLAR G.

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.56, sa.2, ss.545-552, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2310/jim.0b013e3181641ce3
  • Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.545-552
  • Anahtar Kelimeler: atherosclerosis, antioxidant mechanisms, uremia, CHRONIC-RENAL-FAILURE, CARDIOVASCULAR-DISEASE, OXIDATIVE STRESS, PLASMA THIOLS, RISK-FACTORS, ENDOTHELIAL DYSFUNCTION, HEMODIALYSIS-PATIENTS, LIPID-PEROXIDATION, SUPEROXIDE ANION, REDOX STATUS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Oxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosis and oxidative stress have not been clarified yet.