Are uremia, diabetes, and atherosclerosis linked with impaired antioxidant mechanisms?
JOURNAL OF INVESTIGATIVE MEDICINE, vol.56, no.2, pp.545-552, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 56 Issue: 2
- Publication Date: 2008
- Doi Number: 10.2310/jim.0b013e3181641ce3
- Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.545-552
- Keywords: atherosclerosis, antioxidant mechanisms, uremia, CHRONIC-RENAL-FAILURE, CARDIOVASCULAR-DISEASE, OXIDATIVE STRESS, PLASMA THIOLS, RISK-FACTORS, ENDOTHELIAL DYSFUNCTION, HEMODIALYSIS-PATIENTS, LIPID-PEROXIDATION, SUPEROXIDE ANION, REDOX STATUS
- Akdeniz University Affiliated: Yes
Abstract
Background: Oxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosis and oxidative stress have not been clarified yet.