Effects of Botulinum Toxin A Injection on Healing and Tensile Strength of Ruptured Rabbit Achilles Tendons

Tuzuner S., ÖZKAN Ö., ERİN N., Ozkaynak S., CINPOLAT A., ÖZKAN Ö.

ANNALS OF PLASTIC SURGERY, vol.74, no.4, pp.496-500, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1097/sap.0b013e31829aa2e1
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.496-500
  • Keywords: botulinum neurotoxin type-A, immobilization, mobilization, tendon rupture, SKELETAL-MUSCLE, FLEXOR TENDONS, RAT MODEL, REPAIR, MOBILIZATION, IMMOBILIZATION, NEUROTOXINS, SPASTICITY, CHICKENS, COLLAGEN
  • Akdeniz University Affiliated: Yes


Background: Tendon lacerations are most commonly managed with surgical repair. Postoperative complications such as adhesions and ruptures often occur with immobilization. Early postoperative mobilization is therefore advised to minimize complications and time required to return to daily life. The aim of this study was to evaluate whether botulinum neurotoxin type-A (BoNT-A) can be used to enhance healing and prevent rupture in mobilized animals with Achilles tenotomy.