Topical Application of Tacrolimus Prevents Epidural Fibrosis in a Rat Postlaminectomy Model: Histopathological and Ultrastructural Analysis

İSMAİLOĞLU Ö., Albayrak B., Gulsen I., TANRIÖVER G., DEMİR N.

TURKISH NEUROSURGERY, vol.21, no.4, pp.630-633, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.5137/1019-5149.jtn.4954-11.1
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.630-633
  • Keywords: Epidural fibrosis, Laminectomy, Tacrolimus, Rat, LAMINECTOMY SCAR FORMATION, SDZ ASM 981, ANTIINFLAMMATORY DRUG, MITOMYCIN-C, PERIDURAL FIBROSIS, SKIN DISEASES, PHARMACOLOGY, INHIBITION, SURGERY
  • Akdeniz University Affiliated: Yes

Abstract

AIM: Postlaminectomy epidural fibrosis is the formation of scar tissue over the dura mater following posterior spinal surgery. This devastating complication is responsible for the substantial amount of failed back syndromes.