The antioxidant effect of free bilirubin on cumene hydroperoxide treated human leukocytes

Yesilkaya A., Altinayak R., Korgun D.

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, vol.35, no.1, pp.17-20, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2000
  • Doi Number: 10.1016/s0306-3623(01)00084-2
  • Journal Name: GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.17-20
  • Keywords: bilirubin, leukocyte, antioxidant, thiobarbituric acid reactive substances, superoxide dismutase, glutathione concentration, LIPID PEROXIDES, ERYTHROCYTES, NEUTROPHILS, RADICALS, ENZYMES, COPPER
  • Akdeniz University Affiliated: Yes

Abstract

To examine the antioxidant effect of bilirubin (BR) on leukocyte, we treated leukocytes obtained from healthy subjects with an oxidant and various concentrations of BR. High concentrations of BR decreased thiobarbituric acid reactive substances (TBARS) and catalase activities, increased superoxide dismutase (SOD) activity, but had no effect on glutathione (GSH) concentration. Our results showed that under physiological conditions, BR has an antioxidant effect only in high concentrations. (C) 2001 Elsevier Science Inc. All rights reserved.