NT-proBNP levels in beta-thalassemia major patients without cardiac hemosiderosis

Kurtoglu A. U., Karakus V., Kurtoglu E., Bozkurt S.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.1, pp.71-75, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2016-0272
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.71-75
  • Keywords: Beta-thalassemia major, Heart failure, NT-proBNP, Cut-off values, Early detection, VENTRICULAR DIASTOLIC DYSFUNCTION, HEART-FAILURE, IRON, RESONANCE
  • Akdeniz University Affiliated: Yes

Abstract

Introduction: Heart failure due to hemosiderosis is frequent in beta-thalassemia major (beta-TM) patients. Magnetic resonance imaging (MRI) is used in the early detection of heart failure. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a very sensitive marker in the diagnosis of heart failure. In this study, we aimed to investigate the efficacy of NT-proBNP levels in thalassemia patients, who are thought to have no cardiac iron deposition according to T2* scoring system (CMRT2* > 20 msn), in early identification of cardiac failure.