Effect of exogenous melatonin administration on pain threshold in exercise trained rats under light-induced functional pinealectomy

ÖZKAYA M., Gundogdu A., Seyran M., HİNDİSTAN İ. E., Pamuk O., ÖZKAYA Y. G.

BIOLOGICAL RHYTHM RESEARCH, cilt.45, sa.6, ss.849-859, 2014 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 6
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/09291016.2014.923619
  • Dergi Adı: BIOLOGICAL RHYTHM RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.849-859
  • Anahtar Kelimeler: exercise, hypoalgesia, pinealectomy, melatonin, EXHAUSTIVE EXERCISE, BETA-ENDORPHIN, ANALGESIA, MICE, PERCEPTION, MODULATION, FIBROMYALGIA, SENSITIVITY, INVOLVEMENT, NOCICEPTION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Exercise-induced hypoalgesia (EIH) typically reported during and/or following exercise, but less is known the mechanisms responsible for EIH. Previous reports suggest that melatonin plays a role in pain modulation. In this study, we investigated the role of melatonin on pain threshold at rest, and following exercise in both sedentary and exercise trained rats under light-induced functional pinealectomy. Male wistar rats were assigned to one of four groups: sedentary control (C), sedentary pinealectomized (Px), exercise trained (T), and trained under pinealectomy (T-Px) groups. Exercise trained groups were subjected to eight weeks of motor-driven treadmill exercise. C and T groups exposed to normal light/dark cycle (12: 12-h light/dark cycle) and Px and T-Px rats exposed to continuous light for eight weeks. Hot-plate test was repeated before and after melatonin injection and paw withdrawal latencies were recorded as pain threshold. Acute exercise resulted increased pain threshold in all groups. Animals in T group had significantly highest pain thresholds compared with other groups, and pinealectomy resulted decreased pain threshold in trained animals both at rest, and following exercise. Pain threshold in T-Px group was found to be increased after melatonin administration. Our findings support the hypothesis that melatonin plays a role on hypoalgesic response in exercise-trained rats.