Putative roles of soluble trophic factors in facial nerve regeneration, target reinnervation, and recovery of vibrissal whisking

Bendella H., Rink S., Grosheva M., SARIKCIOĞLU L., Gordon T., Angelov D. N.

EXPERIMENTAL NEUROLOGY, cilt.300, ss.100-110, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 300
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.expneurol.2017.10.029
  • Dergi Adı: EXPERIMENTAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.100-110
  • Anahtar Kelimeler: Motoneuron, Axotomy, Functional recovery, vibrissae whisking, Motor endplates, Polyinnervation, NGF, BDNF, IGF, FGF2, CILIARY NEUROTROPHIC FACTOR, FIBROBLAST-GROWTH-FACTOR, RAT SCIATIC-NERVE, POOR FUNCTIONAL RECOVERY, TERMINAL SCHWANN-CELLS, ADULT SENSORY NEURONS, MOTONEURONS IN-VIVO, DEVELOPING NEUROMUSCULAR-JUNCTIONS, MEDIAL GASTROCNEMIUS-MUSCLES, FACTOR GENE-EXPRESSION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

It is well-known that, after nerve transection and surgical repair, misdirected regrowth of regenerating motor axons may occur in three ways. The first way is that the axons enter into endoneurial tubes that they did not previously occupy, regenerate through incorrect fascicles and reinnervate muscles that they did not formerly supply. Consequently the activation of these muscles results in inappropriate movements. The second way is that, in contrast with the precise target-directed pathfinding by elongating motor nerves during embryonic development, several axons rather than a single axon grow out from each transected nerve fiber. The third way of misdirection occurs by the intramuscular terminal branching (sprouting) of each regenerating axon to culminate in some polyinnervation of neuromuscular junctions, i.e. reinnervation of junctions by more than a single axon. Presently, "fascicular" or "topographic specificity" cannot be achieved and hence target-directed nerve regeneration is, as yet, unattainable. Nonetheless, motor and sensory reinnervation of appropriate endoneurial tubes does occur and can be promoted by brief nerve electrical stimulation.