Akademik Veri Yönetim Sistemi
Experimental and Clinical Transplantation, cilt.8, sa.1, ss.49-54, 2010 (SCI-Expanded, Scopus)
Objectives: Our purpose was to investigate the effects of ischemia-reperfusion injury on traumatized lungs. Materials and Methods: Twenty-four Wistar rats were used in the study. Rats were randomly divided into 4 groups. In the control group (group 1), only anesthesia and ventilation were used. In group 2, only lung ischemia-reperfusion injury was instituted. In group 3, only blunt chest trauma was instituted. And in group 4, lung ischemiareperfusion injury, consisting of 24 hours after the constitution of blunt chest trauma, was used. Lung damage and systemic inflammation parameters were evaluated. Results: All parameters (alveolar degeneration grades, alveolar macrophage and lymphocyte counts, antioxidant enzyme activities, cytokine levels, and bronchoalveolar lavage fluid albumin level) were higher in all groups than they were in the control group (P < .05). Only tissue malondialdehyde, tissue interleukin-8, and serum glutathione peroxidase levels were significantly higher in the lung ischemia-reperfusion group than they were in the trauma group (P < .05). The trauma + ischemiareperfusion group showed no significant difference when compared with the only ischemia-reperfusion or only trauma groups in any parameters (P > .05). Conclusions: The findings showed that lung trauma does not aggravate the deleterious effects of lung ischemia-reperfusion injury. Copyright © Başkent University 2010.