Vascular Dilation Responses of Rat Small Mesenteric Arteries at High Intravascular Pressure in Spontaneously Hypertensive Rats

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Guenduez F., Baskurt O. K., Meiselman H. J.

CIRCULATION JOURNAL, cilt.73, sa.11, ss.2091-2097, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 11
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1253/circj.cj-09-0392
  • Dergi Adı: CIRCULATION JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2091-2097
  • Anahtar Kelimeler: Acetylcholine, Flow-mediated dilation, Hypertension, Rats, Sodium nitroprusside, FLOW-INDUCED DILATION, RESISTANCE ARTERIES, NITRIC-OXIDE, ENDOTHELIAL DYSFUNCTION, OXIDATIVE STRESS, BLOOD-PRESSURE, PATHOGENESIS, ANTAGONIST, STRETCH, SHEAR
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Hypertension is associated with remodeling, and mechanical alterations of resistance arteries. Numerous studies have investigated the mechanical and morphometric properties of small arteries obtained front hypertensive animals and humans. However, the functional properties of resistance arteries from normotensive and hypertensive subjects' have only been examined under normotensive conditions The objective of the present study was 10 evaluate the dilation responses of small mesenteric arteries (SMA) front spontaneously hypertensive rats (SHR) at various levels of intraluminal pressure.