Vascular Dilation Responses of Rat Small Mesenteric Arteries at High Intravascular Pressure in Spontaneously Hypertensive Rats

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Guenduez F., Baskurt O. K., Meiselman H. J.

CIRCULATION JOURNAL, vol.73, no.11, pp.2091-2097, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 11
  • Publication Date: 2009
  • Doi Number: 10.1253/circj.cj-09-0392
  • Journal Name: CIRCULATION JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2091-2097
  • Keywords: Acetylcholine, Flow-mediated dilation, Hypertension, Rats, Sodium nitroprusside, FLOW-INDUCED DILATION, RESISTANCE ARTERIES, NITRIC-OXIDE, ENDOTHELIAL DYSFUNCTION, OXIDATIVE STRESS, BLOOD-PRESSURE, PATHOGENESIS, ANTAGONIST, STRETCH, SHEAR
  • Akdeniz University Affiliated: Yes

Abstract

Background: Hypertension is associated with remodeling, and mechanical alterations of resistance arteries. Numerous studies have investigated the mechanical and morphometric properties of small arteries obtained front hypertensive animals and humans. However, the functional properties of resistance arteries from normotensive and hypertensive subjects' have only been examined under normotensive conditions The objective of the present study was 10 evaluate the dilation responses of small mesenteric arteries (SMA) front spontaneously hypertensive rats (SHR) at various levels of intraluminal pressure.