Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs

Donmez, BARIŞ; ÖZDEMİR, SEMİR; SARIKANAT, MEHMET; YARAŞ, NAZMİ; Koc, Pinar; DEMİR, NECDET; Karayalcin, BİNNUR; OĞUZ, NURETTİN

doi:10.1016/s1734-1140(12)70882-4

Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs

Donmez B. Ö., ÖZDEMİR S., SARIKANAT M., YARAŞ N., Koc P., DEMİR N., ...Daha Fazla

PHARMACOLOGICAL REPORTS, cilt.64, sa.4, ss.878-888, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 64 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.1016/s1734-1140(12)70882-4
Dergi Adı: PHARMACOLOGICAL REPORTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.878-888
Anahtar Kelimeler: osteoporosis, biomechanics, bone, angiotensin, ovariectomy, BONE-MINERAL DENSITY, OVARIECTOMIZED RATS, FRACTURE RISK, ESTROGEN, THERAPY, CELLS, COMBINATION, RISEDRONATE, INCREASES, STRENGTH
Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Osteoblasts and osteoclasts are known to express Ang II type I (AT1) receptor in cell cultures, suggesting the existence of local renin-angiotensin system (RAS) in bone. This study was designed to investigate the effects of losartan as AT1 receptor blocker on ovariectomized rats' femur.