Endothelial dysfunction in subjects with subclinical hyperthyroidism

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Coban E., Aydemir M., Yazicibglu G., Özdoğan M.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.29, sa.3, ss.197-200, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/bf03345539
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.197-200
  • Anahtar Kelimeler: cardiovascular risk, enclothelial dysfunction, subclinic hyperthyroidism, von Willebrand factor, VON-WILLEBRAND-FACTOR, THYROID-DISEASE, ATRIAL-FIBRILLATION, RISK FACTOR, ATHEROSCLEROSIS, THYROTOXICOSIS, PLASMA, MARKER, DAMAGE, HEART
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Numerous clinical and experimental reports suggest that a high von Willebrand factor (vWf) level reflects endothelial damage or endothelial dysfunction. The present study was designed to evaluate vWf in subclinical hyperthyroidic subjects compared with euthyroidic subjects. We selected 20 subclinical hyperthyroidic subjects and 20 euthyroidic control subjects matched for age, gender and body mass index. The level of vWf was significantly higher in the subclinical hyperthyroidic group than in the euthyroidic group (42.9 +/- 9.6 vs 37.6 +/- 6.4%, p=0.026). In conclusion, our results suggest that subjects with subclinical hyperthyroidism tend to have an endothelial dysfunction. Endothelial dysfunction could contribute to increasing the cardiovascular risk in subclinical hyperthyroidism.