The Relationship between Insulin Resistance and Hypercoagulability in Acute Ischemic Stroke

Ozkul A., Turgut E., Akyol A., Yenisey C., Kadikoylu G., Tataroglu C., ...Daha Fazla

EUROPEAN NEUROLOGY, cilt.64, sa.4, ss.201-206, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1159/000319196
  • Dergi Adı: EUROPEAN NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.201-206
  • Anahtar Kelimeler: Insulin resistance, Hypercoagulability, Natural anticoagulants, Stroke severity, RANDOMIZED CONTROLLED-TRIAL, BODY-FAT DISTRIBUTION, PROTEIN-S, HEMOSTATIC MARKERS, POSTSTROKE HYPERGLYCEMIA, CARDIOVASCULAR RISK, INTRAVENOUS ANCROD, METABOLIC SYNDROME, PLASMA-FIBRINOGEN, BLOOD-GLUCOSE
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Aim: Insulin resistance has effects on the coagulation system, which is important in the acute phase of infarct. We examined the relationships between insulin resistance, hemostatic markers and stroke severity in acute ischemic stroke patients. Methods: Protein C (PC), protein S (PS), fibrinogen, von Willebrand factor and antithrombin III (AT III) were studied in 75 acute ischemic stroke patients with and without insulin resistance. Results: The PC and PS levels of insulin-resistant patients were significantly lower than those of non-insulin-resistant patients (PC: 87 +/- 19.23 vs. 97.89 +/- 13.3%, p = 0.007; PS: 84.75 +/- 15.72 vs. 93.21 +/- 15.02%, p = 0.02), and both of the anticoagulants were correlated with the homeostasis model assessment (HOMA; r = -0.339, p = 0.003 and r = -0.481, p = 0.000, respectively). Additionally, the NIH Stroke Scale (NIHSS) score correlated negatively with PS (r = -0.329, p = 0.004) and AT III levels (r = -0.235, p = 0.04). The parameters with positive correlations with NIHSS were fibrinogen (r = 0.270, p = 0.019), fasting glucose (r = 0.358, p = 0.008) and HOMA (r = 0.286, p = 0.013). Conclusions: The significant associations between insulin resistance and hemostatic markers may be relevant to stroke severity by causing a procoagulant tendency in acute ischemic stroke. Copyright (C) 2010 S. Karger AG, Basel