TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behcet's disease

Akman A., Sallakci N., Coskun M., Bacanli A., Yavuzer U., Alpsoy E., ...Daha Fazla

BRITISH JOURNAL OF DERMATOLOGY, cilt.155, sa.2, ss.350-356, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 155 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1365-2133.2006.07348.x
  • Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.350-356
  • Anahtar Kelimeler: 1031 T/C, Behcet's disease, ELISPOT, functional polymorphism, TNF-alpha, NECROSIS-FACTOR-ALPHA, RHEUMATOID-ARTHRITIS PATIENTS, CYTOKINE PRODUCTION, 5'-FLANKING REGION, CROHNS-DISEASE, NITRIC-OXIDE, ASSOCIATION, IL-8, JAPANESE, PROTEIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play an important role in development of the disease. The tumour necrosis factor (TNF)-alpha gene, which is closely linked to the HLA-B51 gene, is involved in susceptibility for BD. Recently, a polymorphism at position -1031 within the TNF-alpha promoter region was demonstrated to be responsible for susceptibility to BD in a British population. However, the functional effects of this polymorphism have not yet been determined.