TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behcet's disease
BRITISH JOURNAL OF DERMATOLOGY, cilt.155, sa.2, ss.350-356, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 155 Sayı: 2
- Basım Tarihi: 2006
- Doi Numarası: 10.1111/j.1365-2133.2006.07348.x
- Dergi Adı: BRITISH JOURNAL OF DERMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.350-356
- Anahtar Kelimeler: 1031 T/C, Behcet's disease, ELISPOT, functional polymorphism, TNF-alpha, NECROSIS-FACTOR-ALPHA, RHEUMATOID-ARTHRITIS PATIENTS, CYTOKINE PRODUCTION, 5'-FLANKING REGION, CROHNS-DISEASE, NITRIC-OXIDE, ASSOCIATION, IL-8, JAPANESE, PROTEIN
- Akdeniz Üniversitesi Adresli: Evet
Özet
Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play an important role in development of the disease. The tumour necrosis factor (TNF)-alpha gene, which is closely linked to the HLA-B51 gene, is involved in susceptibility for BD. Recently, a polymorphism at position -1031 within the TNF-alpha promoter region was demonstrated to be responsible for susceptibility to BD in a British population. However, the functional effects of this polymorphism have not yet been determined.