TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behcet's disease


Akman A., Sallakci N., Coskun M., Bacanli A., Yavuzer U., Alpsoy E., ...More

BRITISH JOURNAL OF DERMATOLOGY, vol.155, no.2, pp.350-356, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 155 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1365-2133.2006.07348.x
  • Journal Name: BRITISH JOURNAL OF DERMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.350-356
  • Keywords: 1031 T/C, Behcet's disease, ELISPOT, functional polymorphism, TNF-alpha, NECROSIS-FACTOR-ALPHA, RHEUMATOID-ARTHRITIS PATIENTS, CYTOKINE PRODUCTION, 5'-FLANKING REGION, CROHNS-DISEASE, NITRIC-OXIDE, ASSOCIATION, IL-8, JAPANESE, PROTEIN
  • Akdeniz University Affiliated: Yes

Abstract

Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play an important role in development of the disease. The tumour necrosis factor (TNF)-alpha gene, which is closely linked to the HLA-B51 gene, is involved in susceptibility for BD. Recently, a polymorphism at position -1031 within the TNF-alpha promoter region was demonstrated to be responsible for susceptibility to BD in a British population. However, the functional effects of this polymorphism have not yet been determined.