Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury.

Kor D. J., Iscimen R., Yilmaz M., Brown M. J., Brown D. R., Gajic O.

Intensive care medicine, vol.35, pp.1039-46, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35
  • Publication Date: 2009
  • Doi Number: 10.1007/s00134-009-1421-8
  • Journal Name: Intensive care medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1039-46
  • Keywords: Acute lung injury, Acute respiratory distress syndrome, Multi-organ failure, HMG-CoA reductase inhibitors, Statins, COA REDUCTASE INHIBITOR, ISCHEMIA-REPERFUSION, HOSPITAL MORTALITY, VASCULAR-SURGERY, THERAPY, SEPSIS, PRAVASTATIN, SURVIVAL, MODEL
  • Akdeniz University Affiliated: Yes

Abstract

Preclinical studies suggest that HMG-CoA reductase inhibitors (statins) may attenuate organ dysfunction. We evaluated whether statins are associated with attenuation of lung injury and prevention of associated organ failure in patients with ALI/ARDS.