Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury.

Kor, Daryl; Iscimen, Remzi; Yilmaz, MURAT; Brown, Michael; Brown, Daniel; Gajic, Ognjen

doi:10.1007/s00134-009-1421-8

Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury.

Kor D. J., Iscimen R., Yilmaz M., Brown M. J., Brown D. R., Gajic O.

Intensive care medicine, vol.35, pp.1039-46, 2009 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 35
Publication Date: 2009
Doi Number: 10.1007/s00134-009-1421-8
Journal Name: Intensive care medicine
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1039-46
Keywords: Acute lung injury, Acute respiratory distress syndrome, Multi-organ failure, HMG-CoA reductase inhibitors, Statins, COA REDUCTASE INHIBITOR, ISCHEMIA-REPERFUSION, HOSPITAL MORTALITY, VASCULAR-SURGERY, THERAPY, SEPSIS, PRAVASTATIN, SURVIVAL, MODEL
Akdeniz University Affiliated: Yes

Abstract

Preclinical studies suggest that HMG-CoA reductase inhibitors (statins) may attenuate organ dysfunction. We evaluated whether statins are associated with attenuation of lung injury and prevention of associated organ failure in patients with ALI/ARDS.