Optimal ventilator settings in acute lung injury and acute respiratory distress syndrome.

Yilmaz M., GAJIC O.

European journal of anaesthesiology, vol.25, pp.89-96, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2008
  • Doi Number: 10.1017/s0265021507003006
  • Journal Name: European journal of anaesthesiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-96
  • Keywords: respiration artificial, respiratory distress syndrome adult, high-frequency ventilation, critical care, END-EXPIRATORY PRESSURE, RANDOMIZED CONTROLLED-TRIAL, FREQUENCY OSCILLATORY VENTILATION, HIGH TIDAL VOLUME, MECHANICAL VENTILATION, PROTECTIVE-VENTILATION, HYPERCAPNIC ACIDOSIS, NONINVASIVE VENTILATION, PERMISSIVE HYPERCAPNIA, LIMITED VENTILATION
  • Akdeniz University Affiliated: Yes

Abstract

Despite recent advances in intensive care medicine, acute lung injury and its more severe form, acute respiratory distress syndrome pose major therapeutic problems. While mechanical ventilation is integral to the care of these patients, its adverse consequences including ventilator-induced lung injury are determinants of disease progression and prognosis. Among several important ventilator parameters, the use of low tidal volumes is probably the most important feature of lung-protective mechanical ventilation. Intensivists should be trained to recognize acute lung injury and acute respiratory distress syndrome and encouraged to use low-tidal-volume ventilation in clinical practice. Alternative modes of ventilation such as high-frequency ventilation and prone position should be reserved for selected patients in whom conventional lung-protective ventilation strategies have failed.