Leptin and Ghrelin Levels in Children before and after Adenoidectomy or Adenotonsillectomy


Karalok Z. S., Akdag M., TURHAN M., Uzun G., ÖZDEM S., Dinc O., ...More

HORMONE RESEARCH IN PAEDIATRICS, vol.81, no.1, pp.20-24, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1159/000355508
  • Journal Name: HORMONE RESEARCH IN PAEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.20-24
  • Keywords: Adenoidectomy, Adenotonsillectomy, Obesity, Leptin, Ghrelin, OBSTRUCTIVE SLEEP-APNEA, GROWTH-FACTOR-I, BINDING PROTEIN-3, SERUM-LEVELS, IGF-I, INSULIN, TONSILLECTOMY, OBESITY, IGFBP-3, PATTERN
  • Akdeniz University Affiliated: Yes

Abstract

Background and Aim: Accelerated weight gain after (adeno) tonsillectomy has been reported in a number of studies. Whether (adeno) tonsillectomy is also a risk factor for development of overweight is unknown. We investigated serum leptin and plasma ghrelin levels before and 1 year after (adeno) tonsillectomy operation in children. Materials and Methods: We studied 31 patients and 29 age- and sex-matched healthy control children. Auxologic evaluation and biochemical investigations were performed before surgery and 1 year later. Results: One year after surgery, height SDS (p = 0.001) and weight SDS (p = 0.004) were significantly increased in both groups. No changes in BMI SDS (p = 0.105) were observed. Preoperative leptin levels were significantly higher in patients than controls (p < 0.001). IGF-1, IGFBP-3, HOMA-IR and ghrelin values were not significantly different between the groups. One year after surgery, IGF-1 (p = 0.001) and IGFBP-3 (p = 0.001) were significantly increased, while ghrelin (p < 0.001) was significantly decreased. Postoperative leptin levels of patients were also significantly higher than preoperative values (p = 0.036). Conclusion: Significantly higher leptin levels in patients compared to control both before and 1 year after an obstruction-relieving surgery suggested that higher levels might be due to leptin resistance in these patients. Based on our findings we recommend measurement of leptin levels longitudinally for at least 5 years after adenotonsillectomy. (C) 2013 S. Karger AG, Basel