Polymorphisms of the DNA Repair Genes XPD and XRCC1 and the Risk of Age-Related Macular Degeneration

Gorgun, Ebru; Guven, Mehmet; ÜNAL, MUSTAFA; Batar, Bahadir; Guven, Gulgun; Yenerel, Melda; Tatlipinar, Sinan; SEVEN, Mehmet; Yuksel, Adnan

doi:10.1167/iovs.09-4842

Polymorphisms of the DNA Repair Genes XPD and XRCC1 and the Risk of Age-Related Macular Degeneration

Gorgun E., Guven M., ÜNAL M., Batar B., Guven G. S., Yenerel M., ...More

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol.51, no.9, pp.4732-4737, 2010 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 51 Issue: 9
Publication Date: 2010
Doi Number: 10.1167/iovs.09-4842
Journal Name: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.4732-4737
Akdeniz University Affiliated: Yes

Abstract

PURPOSE. Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme genes, xeroderma pigmentosum complementation group D (XPD), codons 312 and 751, and x-ray cross-complementing group 1 (XRCC1), codons 194 and 399, in patients with AMD and in disease-free control subjects.