Concealed role of red blood cells in pathogenesis of pulmonary arterial hypertension: Decreased red blood cell nitric oxide generation and effect of Rho-Kinase inhibitor fasudil

BAŞARICI İ., ÖZEN N., Kilavuz E., Kisak F., BASRALI F., YARAŞ N., ...Daha Fazla

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.76, sa.4, ss.535-548, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3233/ch-200892
  • Dergi Adı: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.535-548
  • Anahtar Kelimeler: Pulmonary hypertension, eNOS, red blood cell, Rho-Kinase, fasudil, ENDOTHELIAL DYSFUNCTION, INTRAVENOUS FASUDIL, SYNTHASE, PRESSURE, OXYGEN, VASOCONSTRICTION, PHOSPHORYLATION, IDENTIFICATION, HEMOGLOBIN, MECHANISM
  • Akdeniz Üniversitesi Adresli: Evet

Özet

BACKGROUND: Pulmonary arterial hypertension (PAH) is a devastating disease characterized with alterations in pulmonary vasculature yielding increased pulmonary arterial resistance. Emerging evidences suggest important regulatory roles of red blood cells (RBCs) on nitric oxide (NO) bioavailability, mainly by modulating their endothelial nitric oxide synthase (eNOS) enzyme activity.