Concealed role of red blood cells in pathogenesis of pulmonary arterial hypertension: Decreased red blood cell nitric oxide generation and effect of Rho-Kinase inhibitor fasudil

BAŞARICI İ., ÖZEN N., Kilavuz E., Kisak F., BASRALI F., YARAŞ N., ...More

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol.76, no.4, pp.535-548, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.3233/ch-200892
  • Journal Name: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.535-548
  • Keywords: Pulmonary hypertension, eNOS, red blood cell, Rho-Kinase, fasudil, ENDOTHELIAL DYSFUNCTION, INTRAVENOUS FASUDIL, SYNTHASE, PRESSURE, OXYGEN, VASOCONSTRICTION, PHOSPHORYLATION, IDENTIFICATION, HEMOGLOBIN, MECHANISM
  • Akdeniz University Affiliated: Yes

Abstract

BACKGROUND: Pulmonary arterial hypertension (PAH) is a devastating disease characterized with alterations in pulmonary vasculature yielding increased pulmonary arterial resistance. Emerging evidences suggest important regulatory roles of red blood cells (RBCs) on nitric oxide (NO) bioavailability, mainly by modulating their endothelial nitric oxide synthase (eNOS) enzyme activity.