The influence of blood pressure on intracellular Ca2+ content in erythrocytes: Effects of cadmium chloride and nifedipine
CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.18, sa.1, ss.77-86, 1996 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 1
- Basım Tarihi: 1996
- Doi Numarası: 10.3109/10641969609082608
- Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.77-86
- Anahtar Kelimeler: spectrofluorophotometer, CdCl2, nifedipine, fura-2AM, ESSENTIAL-HYPERTENSION, CALCIUM, SODIUM, FLUORESCENCE, MEMBRANE, CELLS, RATS
- Akdeniz Üniversitesi Adresli: Hayır
Özet
Cellular abnormalities associated with elevated Ca2+ concentrations have been postulated to be involved in the pathogenesis of hypertension. The present study was undertaken to investigate the effects of blood pressure changes on cytosolic Ca2+ levels in erythrocytes. Cadmium, which has been implicated in the etiology of hypertension was used as the hypertensive agent and the classical blocker of voltage-operated calcium channels nifedipine was used to treat hypertension. 10 weeks old male rats were divided into four groups; control, CdCl2, CdCl2 and nifedipine, nifedipine groups. CdCl2 caused elevations in blood pressure and in the cytosolic erythrocyte Ca2+ levels both of which were reduced after nifedipine administration. After nifedipine alone, cytosolic Ca2+ levels were increased. These findings suggest that cytosolic Ca2+ content decreasing action of nifedipine in the CdCl2 and nifedipine applied group could be secondary to the antihypertensive action.