Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report

Creative Commons License

KULAKSIZOĞLU B., Kara H., BODUR B., Kuloglu M.

NEUROPSYCHIATRIC DISEASE AND TREATMENT, cilt.14, ss.3033-3035, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2147/ndt.s179688
  • Dergi Adı: NEUROPSYCHIATRIC DISEASE AND TREATMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3033-3035
  • Anahtar Kelimeler: intravenous buprenorphine-naloxone, pregabalin, drug misuse, opioid addiction, DRUG-USERS, ABUSE, DEPENDENCE, NALOXONE, FRANCE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Opioid misuse and dependence are major medical and social concerns worldwide. Buprenorphine/naloxone combination (BNC) is a drug that has misuse potential and is used to treat opioid dependence, including buprenorphine and naloxone. Buprenorphine shows its pharmacological effects by binding to opioid receptors. Buprenorphine is a partial agonist and has smaller maximal effects compared to those of full agonists (heroin, methadone). Naloxone is a non-selective opiate antagonist added to buprenorphine for the prevention of intravenous diversion. BNC is used in the treatment of opioid dependence for detoxification and maintenance. The drug should be used as a sublingual film tablet. Pregabalin is used in the treatment of neuropathic pain, epilepsy and anxiety disorders. It is increasingly being reported as possessing a potential for misuse. In this article, we present a case of intravenous BNC and concomitant oral pregabalin misuse that developed in a monitored and treated patient for the reason of opioid dependence.