Are there any differences in the expression of hormonal receptors and proliferation markers between uterine and extrauterine leiomyomas?

Sen N., Demirkan N. C., Colakoglu N., Duzcan S. E.

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, cilt.16, sa.1, ss.43-47, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/1066896907309576
  • Dergi Adı: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-47
  • Anahtar Kelimeler: uterine, extrauterine, leiomyoma, hormonal receptor, ESTROGEN-RECEPTORS, HUMAN MYOMETRIUM, MENSTRUAL-CYCLE, PROGESTERONE, APOPTOSIS, GROWTH
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The aim of this study is to determine the immunohistochemical expressions of estrogen receptor, progesterone receptor, and Ki-67 proliferation marker in 8 extrauterine leiomyomas and to compare these values with their uterine counterparts. In all, 8 patients with extrauterine leiomyomas and 20 patients with uterine leiomyomas as a control group were studied. Sections were immunohistochemically stained with estrogen receptor, progesterone receptor, and Ki-67 antibodies. Labeling indices for estrogen receptor, progesterone receptor, and Ki-67 were found to be 33.05 % +/- 31.70%, 14.18 % +/- 18.80%, and 0.52 % +/- 1.32% for extrauterine leiomyomas and 65.09% +/- 26.65%, 32.53% +/- 32.80%, and 0.37% +/- 0.71% for uterine leiomyomas, respectively. The difference of labeling indices for progesterone receptor between uterine leiomyomas and extrauterine leiomyomas was statistically significant (P =.002). This study shows that increased expression of progesterone receptor is observed only in uterine leiomyomas during the reproductive period. However, it seems that additional factors to hormone receptors contribute to the development of extrauterine leiomyomas.