Sodium metabisulfite induces lipid peroxidation and apoptosis in rat gastric tissue

Ercan S., Ozturk N., Celik-Ozenci C., Gungor N. E., Yargicoglu P.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.26, sa.7, ss.425-431, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/0748233710369665
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.425-431
  • Anahtar Kelimeler: sodium metabisulfite, lipid peroxidation, apoptosis, gastric tissue, SULFUR-DIOXIDE INHALATION, VISUAL-EVOKED POTENTIALS, CHRONIC RESTRAINT STRESS, OXIDATIVE STRESS, SULFITE, DAMAGE, ACID, PROPOFOL, BISULFITE, CASPASES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Sodium metabisulfite (Na2S2O5) is used as an antioxidant and antimicrobial agent in a variety of drugs and functions as a preservative in many food preparations. This study was performed to elucidate the dose-dependent effects of sodium metabisulfite ingestion on rat gastric tissue apoptotic changes and lipid peroxidation. Forty male wistar rats, aged 3 months were used. They were randomly divided into four groups: control (C), the group treated with Na2S2O5 (10 mg/kg; S1), the group treated with Na2S2O5 (100 mg/kg; S2), the group treated with Na2S2O5 (260 mg/kg; S3). Na2S2O5 was given by intragastric intubation for 35 days. In the S2 and S3 groups, malondialdehyde (MDA) levels increased markedly when compared with the control group. High doses of sulfite administration elevated number of apoptotic cells both in mucosa and submucosa layers of stomach in parallel with increased MDA levels. These results suggest that sodium metabisulfite increased lipid peroxidation and thus number of apoptotic cells on gastric tissue in dose-dependent manner.

Sodium metabisulfite induces lipid peroxidation and apoptosis in rat gastric tissue

By:Ercan, S (Ercan, Sevim)[ 1 ] ; Ozturk, N (Ozturk, Nihal)[ 2 ] ; Celik-Ozenci, C (Celik-Ozenci, Ciler)[ 3 ] ; Gungor, NE (Gungor, Nazli Ece)[ 3 ] ; Yargicoglu, P (Yargicoglu, Piraye)[ 2 ]

 

TOXICOLOGY AND INDUSTRIAL HEALTH

 

Volume: 26

Issue: 7

Pages: 425-431

DOI: 10.1177/0748233710369665

Published: AUG 2010

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TOXICOLOGY AND INDUSTRIAL HEALTH

JCR® Category Quartile in Category
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
in SCIE edition
Q2
TOXICOLOGY Q3

Data from the 2012 edition of Journal Citation Reports®

Publisher SAGE PUBLICATIONS INC, 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA

ISSN: 0748-2337

Research Domain Public, Environmental & Occupational Health
Toxicology

Abstract

Sodium metabisulfite (Na(2)S(2)O(5)) is used as an antioxidant and antimicrobial agent in a variety of drugs and functions as a preservative in many food preparations. This study was performed to elucidate the dose-dependent effects of sodium metabisulfite ingestion on rat gastric tissue apoptotic changes and lipid peroxidation. Forty male wistar rats, aged 3 months were used. They were randomly divided into four groups: control (C), the group treated with Na(2)S(2)O(5) (10 mg/kg; S1), the group treated with Na(2)S(2)O(5) (100 mg/kg; S2), the group treated with Na(2)S(2)O(5) (260 mg/kg; S3). Na(2)S(2)O(5) was given by intragastric intubation for 35 days. In the S2 and S3 groups, malondialdehyde (MDA) levels increased markedly when compared with the control group. High doses of sulfite administration elevated number of apoptotic cells both in mucosa and submucosa layers of stomach in parallel with increased MDA levels. These results suggest that sodium metabisulfite increased lipid peroxidation and thus number of apoptotic cells on gastric tissue in dose-dependent manner.