PAX9 Polymorphisms and susceptibility with sporadic tooth agenesis in Turkish populations: a case-control study

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Isman E., Nergiz S., Acar H., Sari Z.

BMC GENOMICS, cilt.14, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1186/1471-2164-14-733
  • Dergi Adı: BMC GENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: PAX9, Hypodontia, Tooth agenesis, Oral genetics, Polymorphism, RFLP, MOLAR OLIGODONTIA, MUTATION, HUMANS, MSX1, ASSOCIATION, HYPODONTIA, CONTRIBUTE, GENES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Hypodontia, the congenital absence of one or a few teeth is one of the most common alterations of the human dentition. Familial hypodontia is caused by mutations in PAX9, Msx1 and Axin2 genes. Limited numbers of studies are present to show etiological factors beyond this anomaly in Turkish community belonging to Caucasian racial family. The purpose of this study is to investigate the relationships between the two different single nucleotide polymorphisms that are G-1031A and T-912C with hypodontia in Caucasians. 200 individuals having hypodontia and 114 normal individuals having all 32 teeth present were selected for the study. Blood samples were collected from each individual and DNA was extracted. To determine the polymorphisms, PCR-RFLP method was used.