Akademik Veri Yönetim Sistemi
Akdeniz Tıp Dergisi, cilt.10, sa.2, ss.205-215, 2024 (Hakemli Dergi)
Objective: To investigate the variables influencing disease progression and death in chronic renal disease patients (CKD). Material and Methods: The design of this retrospective cohort study was conducted on patients who were referred to the Nephrology Outpatient Clinic with a Glomerular Filtration Rate (GFR) <60 ml/min/1.73 m² in the emergency department and other outpatient clinics of a tertiary hospital between 2009 and 2016. A GFR decline rate of ≥5 ml/min/year was defined as “rapidly progressive” CKD and <5 ml/min/year as “slowly progressive” CKD. The endpoints were renal replacement therapy admission and death. Results: The research comprised 737 patients, with 464 (63%) of them being men. The average duration of follow-up was 16.87 ± 18.55 months. Using the renin-angiotensin- aldosterone system (RAAS) blockers and hyperphosphatemia increased the rate of progression of renal disease. The presence of coronary artery disease and high proteinuria levels increased the hazard of renal replacement therapy (RRT) initiation, whereas statin and vitamin D use decreased this risk. Furthermore, the presence of heart failure, hyperphosphatemia, and anemia raised the risk of death but using RAAS blockers, vitamin D, and high albumin levels lowered the risk of mortality. Conclusion: CKD is a chronic illness with a significant morbidity and death rate. Recognizing and treating the factors that cause the progression of this disease will improve patient survival.