Insertion/Deletion polymorphism of the angiotensin I-converting enzyme gene in patients with breast cancer and effects on prognostic factors
JOURNAL OF INVESTIGATIVE MEDICINE, cilt.55, sa.5, ss.255-261, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 55 Sayı: 5
- Basım Tarihi: 2007
- Doi Numarası: 10.2310/6650.2007.00006
- Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.255-261
- Anahtar Kelimeler: angiotensin-converting enzyyme gene polymorphism, breast cancer, prognostic factors, TYPE-1 RECEPTOR, ACE GENE, CARCINOMA-CELLS, PROSTATE-CANCER, GASTRIC-CANCER, CHINESE WOMEN, GROWTH-FACTOR, TUMOR-GROWTH, RISK, INHIBITORS
- Akdeniz Üniversitesi Adresli: Hayır
Özet
The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DID, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients (p =.03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status (p = .003), tumor size (p = .054), and lymph node involvement (p = .07) but not histologic high grade and c-erb B2 overexpression. These results suggest that the DID genotype may accompany poor prognostic factors and influence the tumor course.