Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?

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CAKIRI T., Basturk A., POLAT C., ASLANER A., DURGUT H., Sehirli A. O., ...More

ACTA CIRURGICA BRASILEIRA, vol.30, no.4, pp.247-254, 2015 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1590/s0102-865020150040000003
  • Journal Name: ACTA CIRURGICA BRASILEIRA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.247-254
  • Keywords: Thioctic Acid, Methotrexate, Liver, Rats, LIPID-PEROXIDATION, PHENETHYL ESTER, STRESS, KIDNEY, MYELOPEROXIDASE, MELATONIN, TOXICITY
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

PURPOSE: To determine the antioxidant and anti-inflammatory effects of alfa lipoic acid (ALA) on the liver injury induced by methotrexate (MTX) in rats.