Endothelial Dysfunction in the Human Umbilical Artery due to Preeclampsia Can Be Prevented by Sildenafil

KARASU E., KAYACAN N., SADAN G., DİNÇ B.

CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.34, sa.2, ss.79-85, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/10641963.2011.628730
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.79-85
  • Anahtar Kelimeler: preeclampsia, sildenafil, nitric oxide, 3 ',5 '-cyclic guanosine monophosphate, phosphodiesterase, K-ATP CHANNELS, NITRIC-OXIDE, DEPENDENT RELAXATION, RESISTANCE ARTERIES, VAGINAL SILDENAFIL, CESAREAN DELIVERY, NORMAL-PREGNANCY, INHIBITOR, MECHANISMS, CITRATE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives. We aimed to determine the effects of sildenafil in human umbilical artery preparation taken from preeclamptic or normal pregnant women, also to investigate underlying mechanisms in these effects. Study design. Eighteen pregnant women with preeclampsia and 18 healthy pregnant women were involved. Relaxation responses of sildenafil in presence and absence of nitric oxide (NO) synthase inhibitor, N-[omega]-nitro-L-arginine methyl ester (L-NAME), and soluble guanylyl cyclase inhibitor, 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one (ODQ), were compared between the preeclampsia group and control group. Results. Sildenafil-induced relaxation responses were significantly attenuated in the presence of preeclampsia, L-NAME or ODQ, but not totally abolished. Interestingly, except with ODQ incubation, in all set of experiments maximal relaxation response was achieved by sildenafil. Conclusion. These data indicate that sildenafil might effect vascular responsiveness of human umbilical artery through the involvement of NO/cyclic guanosine monophosphate (cGMP)-dependent and -independent pathways. Further investigations are needed to clarify the exact mechanisms.