Valproic acid effect on neural tube defects is not prevented by concomitant folic acid supplementation: Early chick embryo model pilot study.

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Atıf İçin Kopyala

TURGUT U., KAZAN S., Cakin H., OZAK A.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, cilt.78, ss.45-48, 2019 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 78
• Basım Tarihi: 2019
• Doi Numarası: 10.1016/j.ijdevneu.2019.05.008
• Dergi Adı: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.45-48
• Anahtar Kelimeler: Folic acid, Valproic acid, Early chicken embryo, Neural tube defect, ANTIEPILEPTIC DRUGS, PREGNANCY, TERATOGENESIS, HOMOCYSTEINE, EXPOSURE, EPILEPSY, CLOSURE, FOLATE, WOMEN, RISK
• Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Neural tube defect is one of the most prevalent congenital malformations and it involves a variety of malformations ranging from anencephaly to spina bifida. Folic acid supplementation during pregnancy is known to reduce risk of neural tube defects. Antiepileptic drugs have been associated with neural tube defects, one of which is valproic acid. Protective effect of folic acid on congenital malformations in patients using valproic acid or other antiepileptic medicines during pregnancy has not clearly been delineated uniformly in previous clinical series. In this experimental animal study of early chick embryo model, we would like to determine if there is any dose-response relationship between VA and NTDs and if there is any protective effect of FA on this relationship in early chick embryo period.