What is novel in the clinical management of pemphigus


BİLGİÇ A., MURRELL D. F.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY, vol.12, no.10, pp.973-980, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 12 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.1080/17512433.2019.1670059
  • Journal Name: EXPERT REVIEW OF CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.973-980
  • Keywords: Pemphigus, treatment, management, targeted therapies, rituximab, BTK inhibitors, ofatumumab, BRUTONS TYROSINE KINASE, SERUM BAFF LEVELS, T-CELL THERAPY, MYCOPHENOLATE-MOFETIL, SYSTEMIC-SCLEROSIS, RITUXIMAB THERAPY, VULGARIS, AUTOIMMUNE, ANTI-CD20, ANTIGEN
  • Akdeniz University Affiliated: Yes

Abstract

Introduction: Pemphigus, an autoimmune disease group characterized by blisters and erosions of the skin and/or mucosal membranes has been treated with systemic corticosteroids (CS) and immunosuppressive therapies for the past few decades. Areas Covered: However, common adverse effects and complications of long-term CS and immunosuppressive drugs are limiting their long-term use. The disease results in death if not treated. Thus, currently, researchers are trying to develop new and safer therapeutic approaches. Specifically, targeted therapies to pathogenic immune pathways are under investigation. The B cell inhibitors which block CD20 and CD19 are the main new drugs investigated in clinical trials as alternatives to systemic steroids. Expert Opinion: Randomized controlled trial (RCT) Level evidence shows that rituximab and short course CSs are more effective and safer than standard CS treatment. Specific BTK inhibitors have shown promise in data from a phase II international open-label study. Further studies are ongoing.