Downregulation of SATB2 is critical for induction of epithelial-to-mesenchymal transition and invasion of NSCLC cells

Kucuksayan H., Ozes O. N., AKÇA H.

LUNG CANCER, vol.98, pp.122-129, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98
  • Publication Date: 2016
  • Doi Number: 10.1016/j.lungcan.2016.05.032
  • Journal Name: LUNG CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.122-129
  • Keywords: SATB2, TGF-beta, NSCLC, EMT, Invasion, Sternness, CANCER STEM-CELLS, LUNG-CANCER, TGF-BETA, BINDING PROTEIN, EMT, SNAIL, FIBROBLASTS, PROGRESSION, METASTASIS, EXPRESSION
  • Akdeniz University Affiliated: Yes

Abstract

Objectives: The epithelial-to-mesenchymal transition (EMT) is considered as a key step in invasion of cancer cells. There are several regulator proteins responsible for induction of EMT, but underlying mechanisms are still unclear. SATB2 is an epigenetic regulator involved in osteoblastic differentiation. The role of SATB2 in EMT and invasion of NSCLC cells is unknown. Therefore, we aimed to explain roles of SATB2 with underlying molecular mechanisms in EMT and invasion of NSCLC cells.