The role of COL6A1and PD-1 expressions in renal cell carcinoma

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Karabulut Y. Y., Kose E. C., Bozlu M., Tuncel F., Yuksek G. E., Etit D., ...More

TURKISH JOURNAL OF UROLOGY, vol.46, no.4, pp.282-287, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.5152/tud.2020.20062
  • Journal Name: TURKISH JOURNAL OF UROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.282-287
  • Keywords: Renal cell carcinoma, COL6A1, PD-1, POOR-PROGNOSIS, SYSTEM
  • Akdeniz University Affiliated: Yes

Abstract

Objective: The COL6A1 is a gene encoding the alpha 1 polypeptide subunit of collagen 6 (COL6A1), an extracellular matrix protein subunit. Programmed cell death receptor-1 (PD-1) and its ligand, programmed cell death receptor ligand-1 (PD-L1) have been shown to have a prognostic significance in clear cell renal cell carcinomas (RCCs). In this study, we evaluated the expressions of COL6A1 and PD-1 in four different RCC subtypes.