The importance of COX-2 expression as prognostic factor in early breast cancer
JOURNAL OF BUON, vol.18, no.3, pp.579-584, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 3
- Publication Date: 2013
- Journal Name: JOURNAL OF BUON
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.579-584
- Keywords: breast cancer, COX-2, cyclooxygenase system, prognostic factors, CYCLOOXYGENASE-2 EXPRESSION, AROMATASE, CELLS, INHIBITION, GROWTH
- Akdeniz University Affiliated: Yes
Abstract
Purpose: A number of studies have been carried out, showing that the risk for breast carcinoma is decreased in those using non-steroidal anti-inflammatory drugs (NSAIDs). Increased cyclooxygenase-2 (COX-2) level is considered as a factor indicating poor prognosis and responsible for angiogenesis, increased cellular proliferation, apoptotic defect and aromatase enzyme induction. For this reason the level of COX-2 might have a prognostic and predictive value in breast cancer as well. This question has become the basis of the present study.