Plasma thiol/disulphide homeostasis changes in patients with relapsing-remitting multiple sclerosis

Ozben S., Kucuksayan E., Koseoglu M., EREL Ö., NEŞELİOĞLU S., Ozben T.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.75, no.7, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1111/ijcp.14241
  • Journal Name: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE
  • Akdeniz University Affiliated: Yes

Abstract

Background Multiple sclerosis (MS) is a neuroinflammatory disease and inflammation and oxidative stress play important roles in its pathology. Thiol/disulphide homeostasis (TDH) is a special oxidative stress biomarker that has been found to be affected in several disorders including MS. There is no study demonstrating the effects of attack status of the relapsing-remitting multiple sclerosis (RRMS) patients on TDH levels. Our aim was to determine TDH levels in three different periods of RRMS patients and healthy individuals.