Catecholestradiol Activation of Adrenergic Receptors Induces Endometrial Cell Survival via p38 MAPK Signaling

Sprague, Rachel; Kim, Joung; KIRIMLIOĞLU, ESMA; Guo, Xiaofang; Gunay, Nihan; Guzeloglu-Kayisli, Ozlem; Ozmen, Asli; Schatz, Frederick; Imudia, Anthony; Lockwood, Charles; Magness, Ronald; Kayisli, Umit

doi:10.1210/clinem/dgaa866

Catecholestradiol Activation of Adrenergic Receptors Induces Endometrial Cell Survival via p38 MAPK Signaling

Sprague R., Kim J. W., KIRIMLIOĞLU E., Guo X., Gunay N., Guzeloglu-Kayisli O., ...Daha Fazla

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.106, sa.2, ss.337-350, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 106 Sayı: 2
Basım Tarihi: 2021
Doi Numarası: 10.1210/clinem/dgaa866
Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, Gender Studies Database, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.337-350
Anahtar Kelimeler: endometriosis, catecholestradiol, endometrial cell survival, p38 MAPK, adrenergic receptor
Akdeniz Üniversitesi Adresli: Evet

Özet

Context: Enhanced levels of catecholestradiols, 2-hydroxyestradiol (2-OHE2) or 4-hydroxyestradiol (4-OHE2), are reported in endometriosis. During gestation, catecholestradiol activation of adrenergic receptors (AR) elevates estrogen receptor (ER)-independent proliferation of uterine arterial endothelial cells.