Akademik Veri Yönetim Sistemi
16th World Congress of Anaesthesiologists (WCA), Hong Kong, PEOPLES R CHINA, 28 Ağustos - 02 Eylül 2016, cilt.123, ss.118
Background & Objectives: Carbon monoxide (CO) is a tasteless, colorless, odorless, nonirritating
and highly toxic gas and it is occurred incomplete combustion of a carbon-containing
fuel. CO intoxication is one of the most common types of fatal gas poisoning. We aimed to
investigate the protective effects of TQ in acute CO poisoning as biochemical and histopathologiacal
examinations.
Materials & Methods: Group Sham (n=15); the rats non exposed CO gas in air or to ambient air at
a rate of 4L/min for 30 min in 16-L Plexiglas chamber. Group TQ (n= 15); TQ was given at a triple
dose (at 0, 12 and 24 hrs) 8mg/kg TQ intraperitoneally in (3 ml DMSO). Group CO (n=15); CO poisoning
was performed according to the published protocol in Plexiglas chambers. Rats breathed
1000 ppm CO for 40 min and then 3000 ppm for up to 20 min, until they lost consciousness;
then they were removed to breathe room air and regain consciousness. Group CO+TQ (n=15); CO
poisoning was performed according to the published protocal in Plexiglas chambers.
Results: Glutatyon and Glutation peroxidase levels were significant higher in CO group
than sham. TQ and TO+CO groups (p<0.05, p<0.01, p<0.05 respectively). Nitric oxide and
Malondialdehyde plasma levels were significant higher in CO group than sham, TQ and TQ+CO
groups (p≤0.001). SOD levels were lower in CO group than sham, TQ and TQ+CO groups
(p≤0.001). There were no statistical significant differences in biochemical parameters between
the sham and TQ group. Also, Nitric oxide levels were significant higher in CO+TQ group than
sham and TQ groups (p≤0.001).
Conclusion: In this study, we have shown that TQ has therapeutic effect on CO poisoninginduced
brain damage by reducing oxidative stres in rat. TQ has potentials as an alternative
treatment for neurologic injury after severe acute CO poisoning.