The effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenoma
ACTA NEUROCHIRURGICA, vol.152, no.9, pp.1611-1617, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 152 Issue: 9
- Publication Date: 2010
- Doi Number: 10.1007/s00701-010-0671-0
- Journal Name: ACTA NEUROCHIRURGICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1611-1617
- Keywords: Hypophyseal adenoma, MMP, Genome, Promoter region, SINGLE NUCLEOTIDE POLYMORPHISM, HUMAN PITUITARY-TUMORS, MATRIX METALLOPROTEINASES, DURAL INVASION, EXPRESSION, TRANSCRIPTION, COLLAGENASE, CANCER, CARCINOMA, BINDING
- Akdeniz University Affiliated: No
Abstract
The matrix metalloproteinase-1 enzyme (MMP-1, also called collagenase 1) plays a key role in turnover of collagen fibers in the intercellular matrix. Insertion of a guanine residue was found within the promoter region of the MMP-1 gene. We found that MMP-1 levels increased approximately twofold over normal when this insertion was present, enabling MMP-1 to facilitate tumor invasion and metastasis. MMP-1 is also believed to play a role in tumor development. The aim of our study is to investigate the effect of polymorphisms in the promoter region of the MMP-1 gene on the development of benign and invasive hypophyseal adenomas.