Dose-dependent effect of nutritional sulfite intake on visual evoked potentials and lipid peroxidation
NEUROTOXICOLOGY AND TERATOLOGY, vol.33, no.2, pp.244-254, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 2
- Publication Date: 2011
- Doi Number: 10.1016/j.ntt.2010.09.002
- Journal Name: NEUROTOXICOLOGY AND TERATOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.244-254
- Keywords: Sulfite, Visual evoked potentials, Lipid peroxidation, SULFUR-DIOXIDE INHALATION, OXIDASE DEFICIENT RATS, SODIUM METABISULFITE, ANTIOXIDANT STATUS, ENZYME-ACTIVITIES, AIR-POLLUTION, GUINEA-PIGS, EXPOSURE, GLUTATHIONE, OXIDATION
- Akdeniz University Affiliated: Yes
Abstract
The aim of this study was to clarify the dose-dependent effect of sulfite (SO32-) ingestion on brain and retina by means of electrophysiological and biochemical parameters. Fifty two male Wistar rats, aged 3 months, were randomized into four experimental groups of 13 rats as follows; control (C), sulfite treated groups (S-1; 10 mg/kg/day, S-2:100 mg/kg/day, S-3; 260 mg/kg/day). Control rats were administered distilled water, while the other three groups were given sodium metabisulfite (Na2S2O5) of amounts mentioned above, via gavage for a period of 35 days.