Urinary N-Acetyl-Beta-D Glucosaminidase Activity is Associated with Inflammation and Proteinuria in Diabetic and Non-Diabetic Patients with Different Stages of Chronic Kidney Disease

Genctoy G., Arikan S.

TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, vol.24, no.2, pp.166-173, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.5262/tndt.2015.1002.05
  • Journal Name: TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.166-173
  • Keywords: Chronic kidney disease, Proteinuria, Inflammation, N-acetyl-beta-D-glucosaminidase, RENAL-DISEASE, REACTIVE PROTEIN, BIOMARKERS, INJURY, MARKER, ALPHA(1)-MICROGLOBULIN, EXCRETION
  • Akdeniz University Affiliated: Yes

Abstract

OBJECTIVE: Clinical studies have demonstrated that tubulointerstitial rather than glomerular pathology correlates with the degree and progression of renal impairment. Urinary n-acetyl-betaD- glucosaminidase (NAG) is a biomarker of tubular damage, shown to be elevated in patients with glomerulonephritis and acute kidney injury. However, it has not been assessed longitudinally in chronic kidney disease (CKD). The aim of the present study was to determine urinary NAG activity and its possible associations with metabolic and inflammatory parameters in CKD.